Nerve Pain

Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. Macquarie Stem Cells treats osteoarthritis, nerve pain can be extremely common with this condition as your joints are surrounded by inflamed nerves.

Your Joints are Full of Nerves.

We talk about innovation quite a lot, but let’s not forget ‘innervation’. This is a medical term used to describe the supply of nerves to vital parts and structures of your body. When discussing nerve pain, two common items come in to mind.

Diabetic Neuropathy
Nerve related disability in the spine

However, there is so much more to it. Nerves are all around your body, they allow you to identify pain or pleasure. In this instance, when Macquarie Stem Cells discusses nerve pain, we are strictly referring to nerves that are present in and around your joints that have become inflamed due to the process of osteoarthritis.

What is Nerve Pain or Neuropathic Pain?

Neuropathic Pain, also known as Neuralgia but much more commonly known as Nerve Pain, this is the sensation of;

  • Burning
  • Tingling
  • Numbness
  • Hot & Cold flushes
  • Pins and Needles
  • Electric shocks, and more;

When nerves are inflamed they send pain signals to the brain all the time instead of only firing when an injury occurs. Neuropathic pain does not start abruptly or resolve quickly; it is a chronic condition which leads to persistent pain symptoms. Although we tend to think of neuropathic pain in association with diabetes or spinal stenosis, it can also occur due injuries to localised joints, the brain, and the spinal cord.  (Patient.info, 2017)


Is it Nociceptive or Neuropathic Pain?

Nociceptive pain

This is caused by damage to tissues. For example, a cut, a burn, an injury, pressure or force from outside the body, or pressure from inside the body (a tumour) can all cause nociceptive pain. The reason we feel pain in these situations is because tiny nerve endings become activated or damaged by the injury, and this sends pain messages to the brain via nerves.

Neuropathic pain

This type of pain is caused by a problem with one or more nerves themselves. The pain sensation is coming from the nerve and not from the surrounding tissues. In simple terms, neuropathic pain can occur without a correlating issue, whereas nociceptive pain occurs due to a current issue your body needs to address. (Patient.info, 2017)


Biological Treatments & Neuropathic Pain

Your body can repair damaged nerves, it is not easy but here are some key points about what your own biological process can achieve’

  • Target and resolve the inflammation that is causing you pain
  • Repair damaged nerve cells
  • Reduce FGF1, GFAP and TNFα expressed proteins
  • Counter nerve cell death (slow or stop the process of the nerves dying)

(Condé-Green et al., 2016) (Wu et al., 2013) (Gibbs et al., 2015) (Jo et al., 2014) (Michalek, 2015) (Sacerdote et al., 2013) (Vickers et al., 2014) (Forouzanfar et al., 2017)

Inflammation is the common pathway for these cells. When your body is not able to resolve new onset damage (acute inflammation), this can progress to chronic inflammation. Acute inflammation is good , when it becomes chronic it is bad. Acute inflammation is part of the healing process. Chronic inflammation causes damage.

We are able to utilise this biological treatment to target and resolve the inflammation around the nerves which will restore normal function. Nerve cells which are damaged have the potential to be repaired; however nerve cells which are completely dead and not functional will not be inflamed, therefore they will not attract our biological intervention.

Additionally, by resolving the inflammation around the damaged nerves, this allows the resident neural repair mechanisms around the area of damage to re-start the repairing process.

This has been confirmed with patient studies of Trigeminal Neuralgia.
(Vickers et al., 2014)

Further Published Documents

There have been many studies utilising biological interventions to treat damaged nerves. This new study provided below, has provided us with strong results.

“New approach for the treatment of neuropathic pain” (Forouzanfar, F. et al. 2017)

Published: 26th of September 2017 in the European Journal of Pain


This study analysed a multi level biological approach to treating chronic constriction injury (CCI).  (Forouzanfar, F. et al. 2017)

The study observed;

  • Mechanical and thermal hypersensitivity
  • Histopathological changes
  • Apoptotic changes
  • FGF1, GFAP and TNFα protein levels

For further clarification: apoptotic changes or “apoptosis” is the death of cells which occurs as a normal part of an organism’s development.


The use of this biological intervention reduced the mechanical and thermal hypersensitivity. Spinal structural alterations and apoptosis were decreased. They found elevated levels of growth factors in the spinal tissue. Overall, the biological therapy lead to a decrease in the level of the neuropathic pain induced TNF-α and GFAP protein levels. (Forouzanfar, F. et al. 2017)


The use of these biological interventions in an intravenous manner could be considered as a potential treatment for the management of neuropathic pain.  (Forouzanfar, F. et al. 2017)


More Medical & Scientific Publications?

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