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Published documents

Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no financial sponsors identified for this study. Before reading this article, it is important for you to understand, here at Macquarie Stem Cells, the biological treatment we perform focuses on treating osteoarthritis as well as issues associated with osteoarthritis.  This publication is the newest Systematic Review available, in the abstract below, the authors briefly touch on conditions such as; inflammatory bowel disease, osteoarthritis, ischemic stroke, multiple sclerosis, myocardial ischemia, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, chronic liver failure, glioblastoma, acute kidney injury, and chronic skin wounds We have a lot of limitations and regulations...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no financial sponsors identified for this study.   Arteries, veins and blood vessels in your body are simply highways, roads and back streets. They allow your blood to travel to many organs and tissues. Blood carries nutrients and oxygen that is essential for your survival. Blocked roads raise concerns... A few blocked back roads may not be such a big drama (small blood vessels) however, if too many of these roads get blocked you run into serious problems. The blockage of these roads (your blood vessels) stops nutrient and oxygen delivery to vital organs, this...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no financial sponsors identified for this study.   KEY TAKE AWAY NOTES: Biological treatments have a huge regenerative and therapeutic potential. Body fat is superior to bone marrow for the purposes of regenerative medicine. Enzyme separation is the most common method of performing biological separation. Automated separation of biological products are required. We need to develop further technologies to fully understand how these treatments work. Guidelines from regulatory bodies are very important to follow. Combining biological treatments with up coming technologies will jump-start other areas of clinical and commercial developments.   TITLE: “Adipose tissue-derived stromal vascular fraction in...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no financial sponsors identified for this study. TITLE: "First-in-man I.V. injection of stromal vascular fraction in psoriasis: a case study." (Comella et al., 2018) Published: 21st March 2018 Journal of Medical Case Reports BACKGROUND: "Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge,...

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Macquarie Stem Cells intent of this article is to inform the public through peer reviewed, published medical papers. We have NOT provided this publication to encourage consumers to seek out such treatments prior to an assessment by a qualified health practitioner. Published: 1st June 2018 Go55's News Paper TITLE: Systematic Review of Biological Treatments for Osteoarthritis The Latest literature review in the Journal of Biomedical Science covers over 1500 patients treated for osteoarthritis with new biological interventions. We understand clinical papers can be difficult to read through, therefore we have re-organised these publications by date order and simply extracted the results of the study directly from the publication. In addition, Dr. Ralph Bright of Macquarie Stem Cells’ publication, “Adipose Derived Stromal Cells to Treat Joint Disease” published in the journal of cosmetic surgery & medicine, pre-dates the earliest publication in this review, therefore we have placed the results directly at...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no financial sponsors identified for this study. TITLE: "Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis" (Koh et al., 2015) Abstract PURPOSE: "In the present study, the clinical outcomes and second-look arthroscopic findings of intra-articular injection of stem cells with arthroscopic lavage for treatment of elderly patients with knee osteoarthritis (OA) were evaluated." (Koh et al., 2015) METHODS: "Stem cell injections combined with arthroscopic lavage were administered to 30 elderly patients (≥65 years) with knee OA. Subcutaneous adipose tissue was harvested from both buttocks by liposuction. After stromal...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. This publication is based on the Macquarie Stem Cells Method that has been patented. There are no financial sponsors of this study. Published: Journal of Evidence Based Medicine & Healthcare - 2015 TITLE: "USE OF AUTOLOGOUS ADIPOSE TISSUE DERIVED STROMAL VASCULAR FRACTION IN TREATMENT OF KNEE OSTEOARTHRITIS AND CHONDRAL LESIONS" (Tantuway et al., 2015) ABSTRACT: "Osteoarthritis is a joint inflammation that results from cartilage degeneration. It can be caused by aging, heredity and injury from trauma or disease. Stromal vascular fraction (SVF), containing large amount of stem cells and other regenerative cells, can be easily obtained from...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature.  This study was funded by Arthrex. Published: Joints Journal - 2017 Successful Treatment of Osgood Schlatter Disease (OSD) Published: September, 2017 PART 1 – OSD treatment based on the publication PART 2 – OSD leading to osteoarthritis treated with based on the publication + biological intervention PART 1 – Introduction Osgood-Schlatter disease is a common cause of knee pain in growing adolescents. It is an inflammation of the area just below the knee where the tendon from the kneecap (patellar tendon) attaches to the shinbone (tibia). Osgood-Schlatter disease most often occurs during growth spurts, when bones, muscles,...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. This project received institutional support by the Italian Ministry of Health Ricerca Finalizzata. Published: Journal of Orthopaedic Surgery - 2016 TITLE "Stem Cells in Articular Cartilage Regeneration" (Guiseppe et al., 2016) A SYSTEMATIC REVIEW - this is now outdated, but it shows how far we have come in a short time frame. More recent review at the bottom of this article Abstract "Mesenchymal stem cells (MSCs) have emerged as a promising option to treat articular defects and early osteoarthritis (OA) stages. However, both their potential and limitations for a clinical use remain controversial. Thus, the aim of this systematic...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. This study was funded by Oxford Musculoskeletal Biomedical Research Unit, National Institute for Health Research. Published: The Lancet - 2017 TITLE: "The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study." (Bayliss et al., 2017) The risk of joint replacement revisions based on the patients age, looking at knees and hips. The text found below is a summary of the population based cohort study. BACKGROUND: "Total joint replacements for end-stage osteoarthritis of the hip and knee are cost-effective and demonstrate significant clinical improvement. However,...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. This study was partly funded by a programme grant of the Dutch Arthritis Foundation for its centre of excellence, Osteoarthritis in Primary Care. Published: British Journal of General Practice - 2016 TITLE: "Defining knee pain trajectories in early symptomatic knee osteoarthritis in primary care: 5-year results" (Bastick et al., 2016) Background "GPs have high consultation rates for symptoms related to knee osteoarthritis (OA). Many risk factors for symptomatic knee OA progression remain unknown." (Bastick et al., 2016) Aim "To define distinct knee pain trajectories in individuals with early symptomatic knee OA and determine the risk factors for these...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no financial sponsors identified for this study. Published: Journal of Medical Case Reports- 2014 TITLE: "Migraine and tension-type headache treated with stromal vascular fraction: a case series" (Bright et al., 2014) Published article by Dr. Ralph Bright, Dr. Matthew Bright and Pelin Bright at Macquarie Stem Cells. INTRODUCTION: "Chronic migraines and tension-type headaches are debilitating diseases affecting 1.4 to 2.2% of the population with both quality of life and economic implications. To date, the pain associated with migraine and tension-type headaches has been controlled with a range of medications, with varying levels of success. In addition,...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. This study has received funding from Osiris Therapeutics, Inc. Published: Current Stem Cell Research & Therapy Journal - 2018 TITLE: "A systematic review and meta-analysis of clinical trials of mesenchymal stem cell therapy for cartilage repair." (Borakati et al., 2018) Review Published 23rd of February 2018 BACKGROUND: "Osteoarthritis (OA) is a major global burden creating significant morbidity worldwide. Current curative therapies are expensive, challenging to access and have significant risks, making them infeasible and difficult in many cases. Mesenchymal stem cells (MSCs) can be applied to joints and may regenerate the cartilage damaged in OA, this therapy may be advantageous to existing treatments."...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no financial sponsors identified for this study. Published: Cancer Research Journal - 2017 A recent publication has uncovered new ground, it appears biological interventions can have a protective effect on cancer cells.  Even though this is very early research, it is looking very positive. TITLE: "A subpopulation of stromal cells controls cancer cell homing to the bone marrow." (Rossnagl et al., 2016) Publication Date: 24th October 2017 Abstract Breast and prostate cancer cells home to the bone marrow where they presumably hijack the hematopoietic stem cell niche. We characterize here the elusive premetastatic niche by examining the role of mesenchymal stromal cells (MSC) in cancer cell homing. Decreasing...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. This study was financially supported by Yoshmi Yashuro of Kyoto University, Sakyo‐ku, Kyoto, Japan. Published: Stem Cells Translational Medicine - 2018 TITLE: "Comparative Analysis of Attitudes on Communication Toward Stem Cell Research and Regenerative Medicine Between the Public and the Scientific Community" (Shineha et al., 2018) Comparison of Understanding Between the Public and the Scientific Community ABSTRACT "Owing to the rapid progress in stem cell research (SCR) and regenerative medicine (RM), society's expectation and interest in these fields are increasing. For effective communication on issues concerning SCR and RM, surveys for understanding the interests of stakeholders is essential. For...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from The Lancet Literature. This article was funded by Arthritis Research UK, the National Institute for Health Research Biomedical Research Centre, and the Royal College of Surgeons (England). Published: The Lancet - 2017 TITLE: "Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial"(Beard et al., 2017) This new study has left medical professionals in a position where they will need to reconsider patient referrals related to shoulder arthroscopies. This  issue affects surgeons all over Australia, unfortunately performing arthroscopies can be their main line of work, their bread and butter. But does it...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. This research was undertaken, in part, thanks to funding from the Canadian Institutes of Health Research. Published: BMJ (Biomedical Journal) - 2016 TITLE: "Cost-effectiveness analysis of arthroscopic surgery compared with non-operative management for osteoarthritis of the knee." (Marsh J., et al, 2016) OBJECTIVE: "To determine the cost-effectiveness of arthroscopic surgery in addition to non-operative treatments compared with non-operative treatments alone in patients with knee osteoarthritis (OA)." (Marsh J., et al, 2016) DESIGN, SETTING AND PARTICIPANTS: "We conducted an economic evaluation alongside a single-centre, randomised trial among patients with symptomatic, radiographic knee OA (KL grade ≥ 2)." (Marsh J., et al, 2016) INTERVENTIONS: "Patients received arthroscopic debridement and partial resection of degenerative knee tissues in addition to optimised non-operative therapy, or optimised non-operative therapy only." (Marsh J., et al, 2016) MAIN OUTCOME MEASURES: "Direct and indirect costs...

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In the past, we have noticed many of our patients who abuse alcohol present reduced results on the day of their treatment. In many cases, we have re-treated patients after they have stopped/reduced the consumption of alcohol and their results have dramatically improved. Note: Some patients break down alcohol very efficiently so the damage is less. Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no sponsors identified for this study. Published: Nature Journal - 2018 TITLE: "Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells." (Garaycoechea J., et al, 2018) Abstract "Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damageinitiates malignancies. Here we describe the features and mutational landscape of...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. This study was funded by a grant from the Aesthetic Surgery Education and Research Foundation (ASERF).   Published: Aesthetic Surgery Journal - 2017 TITLE: "Adipose Stem Cell Function Maintained with Age: An Intra-Subject Study of Long-TermCryopreserved Cells" (Kokai L., et al, 2017) Abstract BACKGROUND: "The progressive decline in tissue mechanical strength that occurs with aging is hypothesized to be due to a loss of resident stem cell number and function. As such, there is concern regarding use of autologous adult stem cell therapy in older patients. To abrogate this, many patients elect to cryopreserve the adipose stromal-vascular fraction (SVF) of lipoaspirate, which contains resident adipose stem cells (ASC). However, it is not clear yet if there is any clinical...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no financial sponsors for this study. Published: Bone Marrow Transplant Journal - 2004 TITLE: "Disappearance of diffuse calcinosis following autologous stem cell transplantation in a child with autoimmune disease" (Elhasid R., et al. 2004) This is a very interesting case, as we were researching about previous interventions/results for fibromyalgia we came across this publication. It was published in 2004, therefore it is not new evidence but we are certain no one has heard of it! Abstract "A 12-year-old girl presented with arthritis, myalgia, anemia and positive ANA. Subsequently, she developed recurrent episodes of pulmonary hemorrhage, thrombocytopenia,...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no financial sponsors for this study. Published: Journal of Stem Cells - 2016 TITLE: "Treatment of AVN Using Autologous BM Stem Cells and Activated Platelet-Derived Growth Factor Concentrates" (Nandeesh N., et al, 2016) Abstract BACKGROUND: "Avascular Necrosis (AVN) of hip is a devastating condition seen in younger individuals. It is the ischemic death of the constituents of the bone cartilage of the hip. The femoral head (FH) is the most common site for AVN. It results from interruption of the normal blood flow to the FH that fits into the hip socket. Earlier studies using autologous bone marrow stem cell concentrate injections have shown encouraging...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. This research was funded by Regenerative Sciences, LLC and the Centeno-Schultz Clinic. Published: Journal of Translational Medicine - 2017 TITLE: "Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy" (Centeno C., et al., 2017) BACKGROUND: "Degenerative disc disease (DDD) is a common cause of lower back pain with radicular symptoms and has a significant socioeconomic impact given the associated disability. Limited effective conservative therapeutic options result in many turning to surgical alternatives for management, which vary in the rate of success and also carry an increased risk of morbidity and mortality associated with...

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Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained from NCBI Pubmed Literature. There are no financial sponsors for this article. Auto-Immune Remission & Biological Treatments Published in the International archives of Medicine Journal in 2012, the clinical use of systemically administered biological treatments has reported in two pilot studies. The first was a description of 3 patients suffering from multiple sclerosis who received an intravenous treatment. All 3 patients reported significant improvement neurologically, and demonstrated an excellent safety profile. Additionally, a patient case report described remission of RA subsequent to administration of a biological intervention. Let’s start by taking a closer look at the biological treatments and their abilities, Migrate to...

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