Knee pain trajectories in early osteoarthritis

April 25,2018

Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. This study was partly funded by a programme grant of the Dutch Arthritis Foundation for its centre of excellence, Osteoarthritis in Primary Care. We aim to provide you with an unbiased range of treatments that are available aside from biological therapy, this is discussed in ‘supporting information>other-options’  page on our website

Published: British Journal of General Practice – 2016

TITLE: “Defining knee pain trajectories in early symptomatic knee osteoarthritis in primary care: 5-year results” (Bastick et al., 2016)


“GPs have high consultation rates for symptoms related to knee osteoarthritis (OA). Many risk factors for symptomatic knee OA progression remain unknown.” (Bastick et al., 2016)


“To define distinct knee pain trajectories in individuals with early symptomatic knee OA and determine the risk factors for these pain trajectories.” (Bastick et al., 2016)

Design and setting

“Data were obtained from the multicentre prospective Cohort Hip and Cohort Knee study in the Netherlands. Participants with knee OA, according to the clinical criteria of the American College of Rheumatology, and a completed 5-year follow-up were included.” (Bastick et al., 2016)


“Baseline demographic, anamnestic, and physical examination characteristics were assessed. Outcome was annually assessed by the Numeric Rating Scale for pain. Pain trajectories were retrieved by latent class growth analysis. Multinomial logistic regression was used to calculate relative risk ratios.” (Bastick et al., 2016)


“In total, 705 participants were included. Six distinct pain trajectories were identified with favourable and unfavourable courses. Statistically significant differences were found in baseline characteristics, including body mass index (BMI), symptom severity, and pain coping strategies between the different trajectories. Higher BMI, lower level of education, greater comorbidity, higher activity limitation scores, and joint space tenderness were more often associated with trajectories characterised by more pain at first presentation and pain progression — compared with the reference group with a mild pain trajectory. No association was found for baseline radiographic features.” (Bastick et al., 2016)


“These results can help differentiate those patients who require more specific monitoring in the management of early symptomatic knee OA from those for whom a ‘wait-and-see’ policy seems justifiable. Radiography provided no additional benefit over clinical diagnosis of early symptomatic knee OA in general practice.” (Bastick et al., 2016)

REF: Bastick, A., Wesseling, J., Damen, J., Verkleij, S., Emans, P., Bindels, P. and Bierma-Zeinstra, S. (2015). Defining knee pain trajectories in early symptomatic knee osteoarthritis in primary care: 5-year results from a nationwide prospective cohort study (CHECK). British Journal of General Practice, 66(642), pp.e32-e39.

TAGS: Macquarie Stem Cells, Dr. Ralph Bright, Treating osteoarthritis, biological treatments, biological interventions


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