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Auto-Immune Remission & Biological Treatments

Auto-Immune Remission & Biological Treatments

April 24,2018

Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained from NCBI Pubmed Literature. There are no financial sponsors for this article. We do not directly treat auto-immune issues.

Auto-Immune Remission & Biological Treatments

Published in the International archives of Medicine Journal in 2012, the clinical use of systemically administered biological treatments has reported in two pilot studies. The first was a description of 3 patients suffering from multiple sclerosis who received an intravenous treatment. All 3 patients reported significant improvement neurologically, and demonstrated an excellent safety profile. Additionally, a patient case report described remission of RA subsequent to administration of a biological intervention.

Let’s start by taking a closer look at the biological treatments and their abilities,

  • Migrate to injured tissue
    Migration includes the ability to travel throughout the vascular system, homing to areas of damage.
  • Differentiate into multiple tissues
    Differentiation is the process where your
  • Release trophic factors
    Trophic Factors support, grow, nourish and feed all the cells in the body.
  • Reduce apoptosis
    Apoptosis is the death of cells which occurs as a normal and controlled part of an organism’s growth or development.
  • Stimulate angiogenesis
    Angiogenesis is the formation of new blood vessels, this improves blood supply to the tissues.
  • Resolve inflammation
    Inflammation is our biological response to harmful stimuli, inflammation causes pain and this is how we identify areas of damage or areas that require our body’s attention. Inflammation is the common pathway for all chronic degenerative disorders. This intervention can remove/reduce inflammation.
  • Stimulate Treg activity (Immune Response)
    T regulatory cells are a component of the immune system that suppresses immune responses of other cells.

(Rohban and Pieber, 2017) (Fu et al., 2017) (Lauvrud et al., 2016) (Nguyen et al., 2016) (Chen et al., 2016) (Zachar, Bačenková and Rosocha, 2016)

The component we are going to focus on here is the stimulation of Treg activity.

What happens when the Treg cells are introduced?

Numerous autoimmune conditions enter remission as a result of increased Treg number and/or activity, whereas relapse is associated with reduction in number and/or activity. Specifically, this has been demonstrated in multiple sclerosis, rheumatoid arthritis and lupus. Given the importance of Treg cells in the control of autoimmunity, it would be useful to possess sources of Treg cells that are easily accessible and can be reintroduced into the patient for immune modulation. (Rodriguez P., et al. 2012)

It is known that the signalling systems known as cytokines leptin and TNF-alpha reduce Treg proliferation and activity. The effects of transferring these signalling systems from a local area through out the body via intravenous infusion has shown to result in enhanced Treg activity for the whole body. (Rodriguez P., et al. 2012)

Given that biological processes including Treg activity are considered to be tolerance-promoting, it may be feasible to consider that the body may enter a tolerance induction stage after the treatment. Rodriguez and Riordan previously reported remission in a patient with rheumatoid arthritis who was treated using biological interventions. Additionally, Riordan’s group and others have reported that increased Treg immune activity is associated with disease remission. (Rodriguez P., et al. 2012)

Ref:Paz Rodriguez, J., Murphy, M., Hong, S., Madrigal, M., March, K., Minev, B., Harman, R., Chen, C., Timmons, R., Marleau, A. and Riordan, N. (2012). Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety. International Archives of Medicine, 5(1), p.5.

Tags: Macquarie Stem Cells, Dr. Bright, Osteoarthritis Treatment, Dr. Ralph Bright, Biological Therapy, Using your own Biology, Rheumatoid arthritis Treatment, Arthritis

 

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