Cigarette Smoking Impairs Your Biological Treatment

June 14,2018

Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no financial sponsors identified for this study.  We aim to provide you with an unbiased range of treatments that are available aside from biological therapy, this is discussed in ‘other-options’  page on our website.


Arteries, veins and blood vessels in your body are simply highways, roads and back streets. They allow your blood to travel to many organs and tissues. Blood carries nutrients and oxygen that is essential for your survival. Blocked roads raise concerns… A few blocked back roads may not be such a big drama (small blood vessels) however, if too many of these roads get blocked you run into serious problems.

The blockage of these roads (your blood vessels) stops nutrient and oxygen delivery to vital organs, this is known as ischemia.
Ischemia can occur in the heart, brain and other organs. This can lead to severe health problems, such as a heart attack or even a stroke. It is not to be taken lightly.

Now, we know and understand smoking cigarettes causes inflammation within your body. We also know inflammation is extremely destructive and causes pain. Past studies have identified smoking actually causes inflammation in your blood vessels, especially in the extremities of your body such as hands and feet.

Do you constant have cold feet? Do you smoke? It could be due to impaired blood vessels around your feet. (but, that’s not for us to diagnose)…
Moving forward, we know biological treatments can resolve inflammation, improve pain, and repair damaged tissues. Much like when we treat osteoarthritis, we see the inflammation resolve within the patients knee, hip, shoulder joint and more, leading to improvements in patients quality of life as well as repairs to their joints. We also know biological treatments can repair damaged tissue such as blood vessels.

Here is what we didn’t know….
The publication below (that is very hard to read) in a nutshell states, not only does smoking cause inflammation in your blood vessels, which leads to damage. Smoking also impairs the ability of the biological treatments to actually repair blood vessels that are inflamed or damaged.

Smoking is not only causing damage, it is impairing your bodies ability to repair the damage that has been caused.

Maybe it’s time to stop……?

Study abstract is below.

TITLE: “Cigarette Smoking Impairs Adipose Stromal Cell Vasculogenic Activity and Abrogates Potency to Ameliorate Ischemia” (Barwinska et al,2018)

Published: 28 March 2018
Stem Cell Journal


“Cigarette smoking (CS) adversely affects the physiologic function of endothelial progenitor, hematopoietic stem and progenitor cells. However, the effect of CS on the ability of adipose stem/stromal cells (ASC) to promote vasculogenesis and rescue perfusion in the context of ischemia is unknown. To evaluate this, ASC from nonsmokers (nCS‐ASC) and smokers (CS‐ASC), and their activity to promote perfusion in hindlimb ischemia models, as well as endothelial cell (EC) survival and vascular morphogenesis in vitro were assessed. While nCS‐ASC improved perfusion in ischemic limbs, CS‐ASC completely lost this therapeutic effect. In vitro vasculogenesis assays revealed that human CS‐ASC and ASC from CS–exposed mice showed compromised support of EC morphogenesis into vascular tubes, and the CS‐ASC secretome was less potent in supporting EC survival/proliferation. Comparative secretome analysis revealed that CS‐ASC produced lower amounts of hepatocyte growth factor (HGF) and stromal cell‐derived growth factor 1 (SDF‐1). Conversely, CS‐ASC secreted the angiostatic/pro‐inflammatory factor Activin A, which was not detected in nCS‐ASC conditioned media (CM). Furthermore, higher Activin A levels were measured in EC/CS‐ASC cocultures than in EC/nCS‐ASC cocultures. CS‐ASC also responded to inflammatory cytokines with 5.2‐fold increase in Activin A secretion, whereas nCS‐ASC showed minimal Activin A induction. Supplementation of EC/CS‐ASC cocultures with nCS‐ASC CM or with recombinant vascular endothelial growth factor, HGF, or SDF‐1 did not rescue vasculogenesis, whereas inhibition of Activin A expression or activity improved network formation up to the level found in EC/nCS‐ASC cocultures. In conclusion, ASC of CS individuals manifest compromised in vitro vasculogenic activity as well as in vivo therapeutic activity. Stem Cells2018;36:856–867″(Barwinska et al,2018)

REF:Barwinska, D., Traktuev, D., Merfeld-Clauss, S., Cook, T., Lu, H., Petrache, I. and March, K. (2018). Cigarette Smoking Impairs Adipose Stromal Cell Vasculogenic Activity and Abrogates Potency to Ameliorate Ischemia. STEM CELLS, 36(6), pp.856-867.

TAGS: Macquarie Stem Cells, Dr. Ralph Bright, Medical Research, Biological treatment, Macquarie Stem Cells biology therapy, Cigarette smoking effects


Remember, any surgical or invasive procedure carries risks. Before proceeding, you should seek a second opinion from an appropriately qualified health practitioner. 

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