Biological Treatments May Decrease Chance Of Cancer Spreading

April 24,2018

Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no financial sponsors identified for this study. We aim to provide you with an unbiased range of treatments that are available aside from biological therapy, this is discussed in ‘supporting information>other-options’  page on our website.

Published: Cancer Research Journal – 2017

A recent publication has uncovered new ground, it appears biological interventions can have a protective effect on cancer cells.  Even though this is very early research, it is looking very positive.

TITLE: “A subpopulation of stromal cells controls cancer cell homing to the bone marrow.” (Rossnagl et al., 2016)

Publication Date: 24th October 2017


Breast and prostate cancer cells home to the bone marrow where they presumably hijack the hematopoietic stem cell niche. We characterize here the elusive premetastatic niche by examining the role of mesenchymal stromal cells (MSC) in cancer cell homing. Decreasing the number of MSC pharmacologically enhanced cancer cell homing to the bone marrow in mice. In contrast, increasing the number of these MSC by various interventions including G-CSF administration diminished cancer cell homing. The MSC subpopulation that correlated best with cancer cells expressed stem, endothelial, and pericytic cell markers suggesting these cells represent an undifferentiated component of the niche with vascular commitment. In humans, a MSC subpopulation carrying markers for endothelial and pericytic cells was lower in the presence of cytokeratin+ cells in bone marrow. Taken together, our data show that a subpopulation of MSC with both endothelial and pericytic cell surface markers suppresses the homing of cancer cells to the bone marrow. Similar to the presence of cytokeratin+ cells in the bone marrow, this mesenchymal stromal cell subpopulation could prove useful in determining the risk of metastatic disease, and its manipulation might offer a new possibility for diminishing bone metastasis formation.

Additional Thoughts

Many other publications have discussed the lack of adverse events associated with biological treatments.  We have successfully treated over 1000 patients with ZERO cancer related incidences.

REF:Rossnagl, S., Ghura, H., Groth, C., Altrock, E., Jakob, F., Schott, S., Wimberger, P., Link, T., Kuhlmann, J., Stenzl, A., Hennenlotter, J., Todenhöfer, T., Rojewski, M., Bieback, K. and Nakchbandi, I. (2017). A subpopulation of stromal cells controls cancer cell homing to the bone marrow. Cancer Research, pp.canres.3507.2016.

TAGS: Macquarie Stem Cells, Dr. Ralph Bright, No Cancer risk from stem cells, Stem Cells may help reduce risk of cancer


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