Alcohol Breaks Down To Aldehyde – Damaging your results

April 24,2018

Macquarie Stem Cells has provided this information to educate the public based on peer reviewed, published scientific and medical documents. We don’t aim to encourage consumers to seek out such treatments prior to an assessment by a health professional to determine your suitability for treatment. This is obtained directly from NCBI Pubmed Literature. There were no sponsors identified for this study. We aim to provide you with an unbiased range of treatments that are available aside from biological therapy, this is discussed in ‘supporting information>other-options’  page on our website.

In the past, we have noticed many of our patients who abuse alcohol present reduced results on the day of their treatment. In many cases, we have re-treated patients after they have stopped/reduced the consumption of alcohol and their results have dramatically improved.

Note: Some patients break down alcohol very efficiently so the damage is less.

Published: Nature Journal – 2018

TITLE: “Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.” (Garaycoechea J., et al, 2018)


“Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damageinitiates malignancies. Here we describe the features and mutational landscape of DNA damage caused by acetaldehyde, an endogenousand alcohol-derived metabolite. This damage results in DNA double-stranded breaks that, despite stimulating recombination repair, also cause chromosome rearrangements. We combined transplantation of single haematopoietic stem cells with whole-genome sequencing to show that this damage occurs in stem cells, leading to deletions and rearrangements that are indicative of microhomology-mediated end-joining repair. Moreover, deletion of p53 completely rescues the survival of aldehyde-stressed and mutated haematopoietic stem cells, but does not change the pattern or the intensity of genome instability within individual stem cells. These findings characterize the mutation of the stem-cell genome by an alcohol-derived and endogenous source of DNA damage. Furthermore, we identify how the choice of DNA-repair pathway and a stringent p53 response limit the transmission of aldehyde-induced mutations in stem cells.” (Garaycoechea J., et al, 2018)

REF: Garaycoechea, J., Crossan, G., Langevin, F., Mulderrig, L., Louzada, S., Yang, F., Guilbaud, G., Park, N., Roerink, S., Nik-Zainal, S., Stratton, M. and Patel, K. (2018). Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature.

TAGS: Macquarie Stem Cells, Dr. Ralph Bright, Alcohol ruins your treatment results


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