Alcohol breaks down to aldehyde which damages Stem Cells

 

In the past, we have noticed many of our patients whom abuse alcohol have significantly lesser stem cells on the day of their treatment. In many cases, we have re-treated patients after they have stopped/reduced the consumption of alcohol and their cell counts have dramatically improved.

Note: Some patients break down alcohol very efficiently so the damage is less.

On the 3rd of January 2018, a scientific document has been published confirming the impact of alcohol on stem cells.

Read this publication below.

Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damage initiates malignancies. Here we describe the features and mutational landscape of DNA damage caused by acetaldehyde, an endogenous and alcohol-derived metabolite. This damage results in DNA double-stranded breaks that, despite stimulating recombination repair, also cause chromosome rearrangements. We combined transplantation of single haematopoietic stem cells with whole-genome sequencing to show that this damage occurs in stem cells, leading to deletions and rearrangements that are indicative of microhomology-mediated end-joining repair. Moreover, deletion of p53 completely rescues the survival of aldehyde-stressed and mutated haematopoietic stem cells, but does not change the pattern or the intensity of genome instability within individual stem cells. These findings characterize the mutation of the stem-cell genome by an alcohol-derived and endogenous source of DNA damage. Furthermore, we identify how the choice of DNA-repair pathway and a stringent p53 response limit the transmission of aldehyde-induced mutations in stem cells.

REF: Garaycoechea, J., Crossan, G., Langevin, F., Mulderrig, L., Louzada, S., Yang, F., Guilbaud, G., Park, N., Roerink, S., Nik-Zainal, S., Stratton, M. and Patel, K. (2018). Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature.

TAGS: Macquarie Stem Cells, Dr. Ralph Bright, Alcohol damages stem cells