We only use Autologous Adult Stem Cells

Autologous means ‘from yourself’, cells from your own body cannot bring any new disease or genes that can weaken your body and will also not be rejected. If we were to culture your cells before reinjecting them, this would be regarded as manufacturing and many more regulations would then be needed. These extra regulations seek to control risks such as infection, disease control and genetic change in the culture. Cultured cells are ten times larger than non-cultured cells. This means they have difficulty getting through the lungs (Pulmonary first pass phenomenon) which filter them out and struggle to cross the blood brain barrier. Non-cultured cells will go into every tissue in the body including the brain and spine.

Allogeneic means from another human (xenogeneic means from an animal or other species) Embryonic and foetal stem cells are all allogeneic, these cells are immune privileged meaning that your body will not recognize them as foreign and will therefore not attack them. However, the problem is that as they differentiate and grow into nerve, muscle skin cells etc. your body will recognize them as foreign and start to destroy them. If you are a close cross match then it will be less likely that you will need to protect them from suppressing your immune system.

Most of the early research has been on embryonic stem cells because they were thought to be more potent as they are able to grow into any cell in the body. Recent work has focused more on adult stem cells which do not make as many different cell types but are proving easier and safer to use.

Anecdotal cases for Many Other Conditions

It is important to keep in mind these cases presented below have shown improvements via stem cell treatments. However Australian Regulations indicate we need to keep our work focused around arthritis and similar degenerative conditions.

Asthma

Asthma can respondwe collect a daily asthma diary for 12 months before the treatment and another 12 months after the treatment to compare the change.

Knight DA et al, Mesenchymal stem cells for repair of the airway epithelium in asthma. Expert Rev Respir Med. 2010 Dec;4(6):747-58

Headache

Migraine and Tension Headache respond so dramatically to Stromal Cell Therapy using StroMed (cells that have been separated using ultrasonic cavitation) that we have filed a patent for this application. We have patients who have achieved 98 and 99% clearing from migraines. Several of these have had headaches for 20 days in every month over many years.

Bright et al Migraine and tension-type headache treated with stromal vascular fraction: a case series, Journal of Medical Case Reports 2014, 8:237

We currently have a migraine trial, if you would like to know if you are eligible go to our trial section and download the application forms. If you are not eligible for the trial it is still possible for you to be treated.

Multiple Sclerosis, Rheumatoid Arthritis

The pathophysiology (the way the disease works) is similar for these diseases but the targets are in different tissues. The immune system often decides that the cells are foreign and therefore tries to destroy them. When the immune system is calm (or quiescent) it won’t attack the cells. At this time it is said to be ‘tolerating’ the cells which is referred to as a state of ‘Tolerogenesis’. Anything that challenges the immune system can cause an attack on your own body. A challenge could be an invading virus or bacteria (infection such as a cold) or it could be physical or emotional stress. The illness or death of someone close is enough to precipitate a decline.

Stromal cells will induce a state of tolerogenesis and help the body to heal itself. Maintaining tolerogenesis is difficult and usually needs an immunosuppressant. good improvements in Rheumatoid Arthritis have been reported amongst patients maintained on Methotrexate who are able to stop all other medication such as prednisone, NSAIDs and paracetamol.

Riordan et al, Autologous Stromal Vascular Fraction Cells: A Tool for Facilitating Tolerance

in Rheumatic Disease, DOI. 10.1016/j.cellimm.2010.04.002

Work from around the world.

Stem cells are the key to future healing

The versatility of the stem cell therapy treatment makes it a very valuable scientific medical procedure. Every month scientists are discovering new ways to use stem cell therapy and so the boundaries of this medical science continues to be extended.

It is important when reading these announcements to be aware of the type of stem cell being used and if they are being used in humans. Many treatments that work in animals do not work in humans.

Missing Teeth

Recently scientists from the National Institute for Health Research in the UK were able to create teeth structures containing enamel, roots and dentine using human and mouse gum tissue. In the future we may be able to grow jaw bone and teeth using stem cell technology.

Wound Healing

Stem cells have been found to aid in the production of blood cells as well as other regenerative cells needed to heal bodily wounds.

Caplan et al, The MSC: An Injury Drugstore, DOI 10.1016/j.stem.2011.06.008

Bone Marrow

Stem cells can be sourced from bone marrow as well as reintroduced to bone marrow via a stem cell transplant to replace damaged cells. Diseases such as leukemia have used this procedure as part of the healing process after chemotherapy.

Wayne AS et al, Hematopoietic stem cell transplantation for leukemia. Pediatr Clin North Am. 2010 Feb;57(1):1-25. doi: 10.1016/j.pcl.2009.11.005.

Spinal Cord Injury

Scientists have seen an improvement in the spasticity and general limb function after applying stem cell therapy to spinal cord injuries in rats. This treatment offers promise to people who have suffered severe spinal injury

McDonald et al, Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord, Nature Medicine 5, 1410 – 1412 (1999)

 

Amyotrophic lateral sclerosis (Lou Gehrig’s/Motor Neuron disease)

Stem cell therapy may possibly be able to regenerate motor neurons which degenerate in patients with ALS. The problem with this treatment at the moment is the amount of motor neurons required to fulfill this treatment.

Gowing et al, Stem cell transplantation for motor neuron disease: current approaches and future perspectives. Neurotherapeutics. 2011 Oct;8(4):591-606. doi: 10.1007/s13311-011-0068-7.

Myocardial Infarction (MI or heart attack)

Studies have shown the stem cells may have the potential to heal damaged areas of the heart post-heart attack.Krishna et al, Myocardial infarction and stem cells, J Pharm Bioallied Sci. 2011 Apr-Jun; 3(2): 182–188.

Muscular Dystrophy

Stem cells have shown potential in regenerating damaged muscle fibres in the body which become affected by muscular dystrophy. They may also possibly reduce inflammation in the affected areas.

Sohn et al, Stem cell therapy for muscular dystrophy. Expert Opin Biol Ther. 2004 Jan;4(1):1-9

Diabetes

Studies have shown that type 1 diabetes may be healed with stem cell therapy. In this treatment stem cells will work to regenerate insulin producing cells which the body’s immune system attacks with type 1 diabetes.

Soria et al, From stem cells to beta cells: new strategies in cell therapy of diabetes mellitus, Diabetologia (2001) 44:407-415

Crohn’s Disease

It has been found that bowel and gastrointestinal destruction caused by Crohn’s Disease may be improved with the use of the regenerative power of stem cell therapy.

Hawkey CJ, Stem cell transplantation for Crohn’s disease, Best Practice & Research Clinical Haematology

Vol. 17, No. 2, pp. 317–325, 2004

Cancers

Stem cell transplants have shown some success in treating cancer patients. When it comes to the treatment of cancer using stem cells, the cells will often be extracted from the patient’s body before they undergo chemotherapy treatment. The stem cells will be stored until after they finish their treatment after which they will then be reinserted to begin the regenerative process.

Wayne AS et al, Hematopoietic stem cell transplantation for leukemia. Pediatr Clin North Am. 2010 Feb;57(1):1-25. doi: 10.1016/j.pcl.2009.11.005.